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Collaboration
with Distinguished Professor and Welsh Chair A.E. Johnson, Department
of Medical Biochemistry and Genetics, College of Medicine: Mechanistic
insights into the integration and potential sorting out the endoplasmic
reticulum membrane of a viral envelope protein that accumulates in viral-induced
membranes within the nucleus.
Goals of proposed research:
- to confirm the
process and compare the protein interactions occurring in the core of
the translocon during viral integral membrane protein primary insertion.
- to assess if there
are potential accessory proteins that function with the translocon during
the sorting process, and to attempt identification of these proteins.
- to interrogate
the functional domains of a signature motif that is sufficient to target
integral membrane proteins to nuclear membranes.
Visit
Dr. Johnson's Web Site
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